Mechanical cell competition kills cells via induction of lethal p53 levels

Mechanical cell competition kills cells via induction of lethal p53 levels

Cell competition is a quality control mechanism to eliminate unfit cells. Here the authors show that physical compaction of less fit cells surrounded by healthy neighbours leads to increased expression of tumour suppressor p53 in the compacted cells, causing cell death.

Bibliographic Details
Main Authors: Laura Wagstaff, Maja Goschorska, Kasia Kozyrska, Guillaume Duclos, Iwo Kucinski, Anatole Chessel, Lea Hampton-O’Neil, Charles R. Bradshaw, George E. Allen, Emma L. Rawlins, Pascal Silberzan, Rafael E. Carazo Salas, Eugenia Piddini
Format: Article
Language:English
Published: Nature Portfolio 2016-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11373

Internet

https://doi.org/10.1038/ncomms11373

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