Noonan syndrome gain-of-function mutations in NRAS cause zebrafish gastrulation defects

Noonan syndrome gain-of-function mutations in NRAS cause zebrafish gastrulation defects

SUMMARY Noonan syndrome is a relatively common developmental disorder that is characterized by reduced growth, wide-set eyes and congenital heart defects. Noonan syndrome is associated with dysregulation of the Ras–mitogen-activated-protein-kinase (MAPK) signaling pathway. Recently, two mutations in...

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Bibliographic Details
Main Authors: Vincent Runtuwene, Mark van Eekelen, John Overvoorde, Holger Rehmann, Helger G. Yntema, Willy M. Nillesen, Arie van Haeringen, Ineke van der Burgt, Boudewijn Burgering, Jeroen den Hertog
Format: Article
Language:English
Published: The Company of Biologists 2011-05-01
Series:Disease Models & Mechanisms
Online Access:http://dmm.biologists.org/content/4/3/393

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http://dmm.biologists.org/content/4/3/393

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