Vaccination by Two DerG LEAPS Conjugates Incorporating Distinct Proteoglycan (PG, Aggrecan) Epitopes Provides Therapy by Different Immune Mechanisms in a Mouse Model of Rheumatoid Arthritis

Vaccination by Two DerG LEAPS Conjugates Incorporating Distinct Proteoglycan (PG, Aggrecan) Epitopes Provides Therapy by Different Immune Mechanisms in a Mouse Model of Rheumatoid Arthritis

Rheumatoid arthritis (RA) can be initiated and driven by immune responses to multiple antigenic epitopes including those in cartilage proteoglycan (PG, aggrecan) and type II collagen. RA is driven by T helper 1 (Th1) or Th17 pro-inflammatory T cell responses. LEAPS (Ligand Epitope Antigen Presentati...

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Bibliographic Details
Main Authors: Daniel H. Zimmerman, Katalin Mikecz, Adrienn Markovics, Roy E. Carambula, Jason C. Ciemielewski, Daniel M. Toth, Tibor T. Glant, Ken S. Rosenthal
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Vaccines
Subjects:
peptide vaccine
immunotherapy
rheumatoid arthritis
Proteoglycan (PG, aggrecan)
PG G1 domain-induced arthritis
Online Access:https://www.mdpi.com/2076-393X/9/5/448

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https://www.mdpi.com/2076-393X/9/5/448

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