Vaccination by Two DerG LEAPS Conjugates Incorporating Distinct Proteoglycan (PG, Aggrecan) Epitopes Provides Therapy by Different Immune Mechanisms in a Mouse Model of Rheumatoid Arthritis
Rheumatoid arthritis (RA) can be initiated and driven by immune responses to multiple antigenic epitopes including those in cartilage proteoglycan (PG, aggrecan) and type II collagen. RA is driven by T helper 1 (Th1) or Th17 pro-inflammatory T cell responses. LEAPS (Ligand Epitope Antigen Presentati...
Main Authors: | Daniel H. Zimmerman, Katalin Mikecz, Adrienn Markovics, Roy E. Carambula, Jason C. Ciemielewski, Daniel M. Toth, Tibor T. Glant, Ken S. Rosenthal |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-05-01
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Series: | Vaccines |
Subjects: | |
Online Access: | https://www.mdpi.com/2076-393X/9/5/448 |
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