Genome-wide aberrant methylation in primary metastatic UM and their matched metastases

Genome-wide aberrant methylation in primary metastatic UM and their matched metastases

Abstract Uveal melanoma (UM) is an aggressive intra-ocular cancer with a strong tendency to metastasize. Metastatic UM is associated with mutations in BAP1 and SF3B1, however only little is known about the epigenetic modifications that arise in metastatic UM. In this study we aim to unravel epigenet...

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Bibliographic Details
Main Authors: Kyra N. Smit, Ruben Boers, Jolanda Vaarwater, Joachim Boers, Tom Brands, Hanneke Mensink, Robert M. Verdijk, Wilfred F. J. van IJcken, Joost Gribnau, Annelies de Klein, Emine Kilic
Format: Article
Language:English
Published: Nature Portfolio 2022-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-03964-8

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https://doi.org/10.1038/s41598-021-03964-8

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