MYC is a regulator of androgen receptor inhibition-induced metabolic requirements in prostate cancer

MYC is a regulator of androgen receptor inhibition-induced metabolic requirements in prostate cancer

Summary: Advanced prostate cancers are treated with therapies targeting the androgen receptor (AR) signaling pathway. While many tumors initially respond to AR inhibition, nearly all develop resistance. It is critical to understand how prostate tumor cells respond to AR inhibition in order to exploi...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Preston D. Crowell, Jenna M. Giafaglione, Anthony E. Jones, Nicholas M. Nunley, Takao Hashimoto, Amelie M.L. Delcourt, Anton Petcherski, Raag Agrawal, Matthew J. Bernard, Johnny A. Diaz, Kylie Y. Heering, Rong Rong Huang, Jin-Yih Low, Nedas Matulionis, Nora M. Navone, Huihui Ye, Amina Zoubeidi, Heather R. Christofk, Matthew B. Rettig, Robert E. Reiter, Michael C. Haffner, Paul C. Boutros, Orian S. Shirihai, Ajit S. Divakaruni, Andrew S. Goldstein
Formatua:	Artikulua
Hizkuntza:	English
Argitaratua:	Elsevier 2023-10-01
Saila:	Cell Reports
Gaiak:	CP: Cancer CP: Metabolism
Sarrera elektronikoa:	http://www.sciencedirect.com/science/article/pii/S2211124723012330

Antzeko izenburuak

ZFP36-mediated mRNA decay regulates metabolism
nork: Andrew C. Cicchetto, et al.
Argitaratua: (2023-05-01)

Uptake of tumor-derived microparticles induces metabolic reprogramming of macrophages in the early metastatic lung
nork: Kelly Kersten, et al.
Argitaratua: (2023-06-01)

Endothelial Jagged1 levels and distribution are post-transcriptionally controlled by ZFP36 decay proteins
nork: Hannah L. Sunshine, et al.
Argitaratua: (2024-01-01)

AAV5-mediated manipulation of insulin expression in choroid plexus has long-term metabolic and behavioral consequences
nork: Caio Henrique Mazucanti, et al.
Argitaratua: (2023-08-01)

Comparative transcriptomic profiling reveals a role for Olig1 in promoting axon regeneration
nork: Xiu-Qing Fu, et al.
Argitaratua: (2024-07-01)

Genetically modified IL2 bone-marrow-derived myeloid cells reprogram the glioma immunosuppressive tumor microenvironment
nork: Alessandro Canella, et al.
Argitaratua: (2023-08-01)

Bordetella spp. block eosinophil recruitment to suppress the generation of early mucosal protection
nork: Nicholas J. First, et al.
Argitaratua: (2023-11-01)

Five autism-associated transcriptional regulators target shared loci proximal to brain-expressed genes
nork: Siavash Fazel Darbandi, et al.
Argitaratua: (2024-06-01)

Hexokinase 2-mediated metabolic stress and inflammation burden of liver macrophages via histone lactylation in MASLD
nork: Jinyang Li, et al.
Argitaratua: (2025-03-01)

Comparing neoantigen cancer vaccines and immune checkpoint therapy unveils an effective vaccine and anti-TREM2 macrophage-targeting dual therapy
nork: Sunita Keshari, et al.
Argitaratua: (2024-11-01)

The HLA-II immunopeptidome of SARS-CoV-2
nork: Shira Weingarten-Gabbay, et al.
Argitaratua: (2024-01-01)

IL-37 dampens immunosuppressive functions of MDSCs via metabolic reprogramming in the tumor microenvironment
nork: Yu Mei, et al.
Argitaratua: (2024-03-01)

Parent-of-origin-specific DNA replication timing is confined to large imprinted regions
nork: Matthew M. Edwards, et al.
Argitaratua: (2024-09-01)

A versatile pumpless multi-channel fluidics system for maintenance and real-time functional assessment of tissue and cells
nork: Varun Kamat, et al.
Argitaratua: (2023-11-01)

The genome of Stephania japonica provides insights into the biosynthesis of cepharanthine
nork: Zhuo Liu, et al.
Argitaratua: (2024-03-01)

“Forcing” new interpretations of molecular tension sensor studies
nork: Matthew R. Pawlak, et al.
Argitaratua: (2024-07-01)

Cells use multiple mechanisms for cell-cycle arrest upon withdrawal of individual amino acids
nork: Yao Rong, et al.
Argitaratua: (2023-12-01)

Tumor eradication by hetIL-15 locoregional therapy correlates with an induced intratumoral CD103intCD11b+ dendritic cell population
nork: Dimitris Stellas, et al.
Argitaratua: (2023-05-01)

A microRNA-regulated transcriptional state defines intratumoral CD8+ T cells that respond to immunotherapy
nork: William W. Tang, et al.
Argitaratua: (2025-02-01)

PANAMA-enabled high-sensitivity dual nanoflow LC-MS metabolomics and proteomics analysis
nork: Weiwei Lin, et al.
Argitaratua: (2024-07-01)

XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells
nork: Tao Zou, et al.
Argitaratua: (2024-02-01)

ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer
nork: Nakisa Tabrizian, et al.
Argitaratua: (2023-08-01)

A reverse transcriptase controls prophage genome reduction to promote phage dissemination in Pseudomonas aeruginosa biofilms
nork: Yunxue Guo, et al.
Argitaratua: (2024-11-01)

Angiotensin AT1A receptor signal switching in Agouti-related peptide neurons mediates metabolic rate adaptation during obesity
nork: Kirthikaa Balapattabi, et al.
Argitaratua: (2023-08-01)

Distinct myeloid population phenotypes dependent on TREM2 expression levels shape the pathology of traumatic versus demyelinating CNS disorders
nork: Han Gao, et al.
Argitaratua: (2023-06-01)

High-throughput identification of calcium-regulated proteins across diverse proteomes
nork: Timothy M. Locke, et al.
Argitaratua: (2024-11-01)

The genomic and evolutionary landscapes of anaplastic thyroid carcinoma
nork: Peter Y.F. Zeng, et al.
Argitaratua: (2024-03-01)

Smooth muscle cell-derived Cxcl12 directs macrophage accrual and sympathetic innervation to control thermogenic adipose tissue
nork: Derek Lee, et al.
Argitaratua: (2024-05-01)

Clostridioides difficile toxin B subverts germinal center and antibody recall responses by stimulating a drug-treatable CXCR4-dependent mechanism
nork: Kaylee M. Norman, et al.
Argitaratua: (2024-05-01)

JAML immunotherapy targets recently activated tumor-infiltrating CD8+ T cells
nork: Simon Eschweiler, et al.
Argitaratua: (2023-02-01)

CD115+ monocytes protect microbially experienced mice against E. coli-induced sepsis
nork: Matthew D. Martin, et al.
Argitaratua: (2023-11-01)

Iron overload in hypothalamic AgRP neurons contributes to obesity and related metabolic disorders
nork: Yi Zhang, et al.
Argitaratua: (2024-03-01)

Epigenomic signatures of sarcomatoid differentiation to guide the treatment of renal cell carcinoma
nork: Talal El Zarif, et al.
Argitaratua: (2024-06-01)

Acute and persistent responses after H5N1 vaccination in humans
nork: Richard Apps, et al.
Argitaratua: (2024-09-01)

FAM193A is a positive regulator of p53 activity
nork: Maria M. Szwarc, et al.
Argitaratua: (2023-03-01)

Insulin receptor signaling engages bladder urothelial defenses that limit urinary tract infection
nork: Laura Schwartz, et al.
Argitaratua: (2024-04-01)

Transcriptional programming mediated by the histone demethylase KDM5C regulates dendritic cell population heterogeneity and function
nork: Hannah Guak, et al.
Argitaratua: (2024-08-01)

Experimental bacterial dysbiosis with consequent immune alterations increase intrarectal SIV acquisition susceptibility
nork: Alexandra M. Ortiz, et al.
Argitaratua: (2023-01-01)

Phosphoprotein dynamics of interacting T cells and tumor cells by HySic
nork: Sofía Ibáñez-Molero, et al.
Argitaratua: (2024-01-01)

An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma
nork: Stephanie M. Casillo, et al.
Argitaratua: (2024-01-01)