Genetic variation in CSF2 (5q31.1) is associated with longitudinal susceptibility to pediatric malaria, severe malarial anemia, and all-cause mortality in a high-burden malaria and HIV region of Kenya

Genetic variation in CSF2 (5q31.1) is associated with longitudinal susceptibility to pediatric malaria, severe malarial anemia, and all-cause mortality in a high-burden malaria and HIV region of Kenya

Abstract Plasmodium falciparum infections remain among the leading causes of morbidity and mortality in holoendemic transmission areas. Located within region 5q31.1, the colony-stimulating factor 2 gene (CSF2) encodes granulocyte–macrophage colony-stimulating factor (GM-CSF), a hematopoietic growth...

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Bibliographic Details
Main Authors: Lily E. Kisia, Qiuying Cheng, Evans Raballah, Elly O. Munde, Benjamin H. McMahon, Nick W. Hengartner, John M. Ong’echa, Kiprotich Chelimo, Christophe G. Lambert, Collins Ouma, Prakasha Kempaiah, Douglas J. Perkins, Kristan A. Schneider, Samuel B. Anyona
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Tropical Medicine and Health
Subjects:
P. falciparum
CSF2
GM-CSF
Malaria
Genotypes
Haplotypes
Online Access:https://doi.org/10.1186/s41182-022-00432-5

Internet

https://doi.org/10.1186/s41182-022-00432-5

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