Patient-Specific Lymphocyte Loss Kinetics as Biomarker of Spleen Dose in Patients Undergoing Radiation Therapy for Upper Abdominal Malignancies

Patient-Specific Lymphocyte Loss Kinetics as Biomarker of Spleen Dose in Patients Undergoing Radiation Therapy for Upper Abdominal Malignancies

Purpose: Radiation therapy (RT)–induced lymphopenia (RIL) is linked with inferior survival in esophageal and pancreatic cancers. Previous work has demonstrated a correlation between spleen dose and RIL risk. The present study correlates spleen dose-volume parameters with fractional lymphocyte loss r...

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Main Authors: Anirudh Yalamanchali, MS, BS, Hong Zhang, PhD, MS, Ke Colin Huang, PhD, Radhe Mohan, PhD, Steven H. Lin, MD, PhD, Cong Zhu, MPH, Stuart A. Grossman, MD, Jian-Yue Jin, PhD, Susannah G. Ellsworth, MD
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Advances in Radiation Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S245210942030213X

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http://www.sciencedirect.com/science/article/pii/S245210942030213X

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