Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brains

Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brains

Abstract Background Alpha-synuclein (α-syn) aggregation into proteinaceous intraneuronal inclusions, called Lewy bodies (LBs), is the neuropathological hallmark of Parkinson’s disease (PD) and related synucleinopathies. However, the exact role of α-syn inclusions in PD pathogenesis remains elusive....

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Bibliographic Details
Main Authors: Morgan Bérard, Laura Martínez-Drudis, Razan Sheta, Omar M. A. El-Agnaf, Abid Oueslati
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Molecular Neurodegeneration
Subjects:
Alpha-synuclein
Adeno-associated virus
AAV-PHP.eB
Neurodegeneration
Parkinson’s Disease
Animal model
Online Access:https://doi.org/10.1186/s13024-023-00683-8

Internet

https://doi.org/10.1186/s13024-023-00683-8

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