Protective immunity of single and multi-antigen DNA vaccines against schistosomiasis

We evaluated the usefulness of the combination of three plasmids encoding tegumental (pECL and pSM14) and muscular (pIRV5) antigens of the Schistosoma mansoni on improving the protective immunity over the use of a single antigen as DNA vaccines. Female BALB/c mice were inoculated twice with 25 µg DN...

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Bibliographic Details
Main Authors: E Nascimento, IC Leão, VRA Pereira, YM Gomes, P Chikhlikar, T August, E Marques, N Lucena-Silva
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2002-10-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762002000900021