Thermodynamic Analysis for Binding of 4-O-β-tri-N-acetylchitotriosyl Moranoline, a Transition State Analogue Inhibitor for Hen Egg White Lysozyme

Thermodynamic Analysis for Binding of 4-O-β-tri-N-acetylchitotriosyl Moranoline, a Transition State Analogue Inhibitor for Hen Egg White Lysozyme

4-O-β-tri-N-acetylchitotriosyl moranoline (GN3M) is a transition-state analogue for hen egg white lysozyme (HEWL) and identified as the most potent inhibitor till date. Isothermal titration calorimetry experiments provided the thermodynamic parameters for binding of GN3M to HEWL and revealed that th...

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Bibliographic Details
Main Authors: Makoto Ogata, Tamo Fukamizo, Takayuki Ohnuma
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Molecular Biosciences
Subjects:
4-O-β-tri-N-acetylchitotriosyl moranoline
lysozyme (HEWL)
thermodynamics
inhibitor
binding
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.654706/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.654706/full

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