Phosphorylation of insulin receptor substrates (IRS-1 and IRS-2) is attenuated following cecal ligation and puncture in mice

Phosphorylation of insulin receptor substrates (IRS-1 and IRS-2) is attenuated following cecal ligation and puncture in mice

Abstract Background Sepsis is characterized as an insulin resistant state. However, the effects of sepsis on insulin’s signal transduction pathway are unknown. The molecular activity driving insulin signaling is controlled by tyrosine phosphorylation of the insulin receptor β-subunit (IRβ) and of in...

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Bibliographic Details
Main Authors: Deepa Mathew, Julia Barillas-Cerritos, Ana Nedeljkovic-Kurepa, Mabel Abraham, Matthew D. Taylor, Clifford S. Deutschman
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Molecular Medicine
Subjects:
Sepsis
Cecal ligation and puncture
CLP
Insulin
Insulin receptor substrate
Tyrosine phosphorylation
Online Access:https://doi.org/10.1186/s10020-023-00703-9

Internet

https://doi.org/10.1186/s10020-023-00703-9

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