Structural basis of human SNAPc recognizing proximal sequence element of snRNA promoter

This study presenting the cryo-EM structure of human SNAPc in complex with U6-1 PSE, significantly enforces our understanding of the mechanism of the SNAPc assembly, the PSE-specific recognition by SNAPc and the PIC assembly on U6 snRNA promoter.

Bibliographic Details
Main Authors: Jianfeng Sun, Xue Li, Xuben Hou, Sujian Cao, Wenjin Cao, Ye Zhang, Jinyang Song, Manfu Wang, Hao Wang, Xiaodong Yan, Zengpeng Li, Robert G. Roeder, Wei Wang
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34639-1