The NF-ĸB p50 subunit generated by KPC1-mediated ubiquitination and limited proteasomal processing, suppresses tumor growth

The NF-ĸB p50 subunit generated by KPC1-mediated ubiquitination and limited proteasomal processing, suppresses tumor growth

Abstract Nuclear factor-ĸB (NF-ĸB) is an important transcriptional regulator of key cellular processes, including cell cycle, immune response, and malignant transformation. We found that the ubiquitin ligase Kip1 ubiquitination-promoting complex subunit 1 (KPC1; also known as Ring finger protein 123...

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Bibliographic Details
Main Authors: Yelena Kravtsova-Ivantsiv, Gilad Goldhirsh, Ciprian Tomuleasa, Eli Pikarsky, Aaron Ciechanover
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Cancer Cell International
Subjects:
NF-ĸB p50
Tumor-suppression
PDL1
KPC1
PROTAC
Chemokines
Online Access:https://doi.org/10.1186/s12935-023-02919-5

Internet

https://doi.org/10.1186/s12935-023-02919-5

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