Adverse transverse-tubule remodeling in a rat model of heart failure is attenuated with low-dose triiodothyronine treatment

Adverse transverse-tubule remodeling in a rat model of heart failure is attenuated with low-dose triiodothyronine treatment

Abstract Pre-clinical animal studies have shown that triiodothyronine (T3) replacement therapy improves cardiac contractile function after myocardial infarction (MI). We hypothesized that T3 treatment could prevent adverse post-infarction cardiomyocyte remodeling by maintaining transverse-tubule (TT...

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Bibliographic Details
Main Authors: Shimin An, Nimra Gilani, Yuan Huang, Adam Muncan, Youhua Zhang, Yi-Da Tang, A. Martin Gerdes, Kaie Ojamaa
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Molecular Medicine
Subjects:
Heart failure
T-tubules
Triiodothyronine
Calcium transients
Contractility
Online Access:https://doi.org/10.1186/s10020-019-0120-3

Internet

https://doi.org/10.1186/s10020-019-0120-3

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