Cancer associated fibroblasts: phenotypic and functional heterogeneity
Cancer associated fibroblasts (CAFs) are the most abundant stromal cell-type in solid tumor-microenvironment (TME) and have emerged as key player in tumor progression. CAFs establish communication with cancer cells through paracrine mechanisms or via direct cell adhesion as well as influence the can...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
IMR Press
2020-03-01
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Series: | Frontiers in Bioscience-Landmark |
Subjects: | |
Online Access: | https://www.imrpress.com/journal/FBL/25/5/10.2741/4843 |