Cancer associated fibroblasts: phenotypic and functional heterogeneity
Cancer associated fibroblasts (CAFs) are the most abundant stromal cell-type in solid tumor-microenvironment (TME) and have emerged as key player in tumor progression. CAFs establish communication with cancer cells through paracrine mechanisms or via direct cell adhesion as well as influence the can...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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IMR Press
2020-03-01
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| Series: | Frontiers in Bioscience-Landmark |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/FBL/25/5/10.2741/4843 |
| _version_ | 1818269438684692480 |
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| author | Ankit Kumar Patel Sandeep Singh |
| author_facet | Ankit Kumar Patel Sandeep Singh |
| author_sort | Ankit Kumar Patel |
| collection | DOAJ |
| description | Cancer associated fibroblasts (CAFs) are the most abundant stromal cell-type in solid tumor-microenvironment (TME) and have emerged as key player in tumor progression. CAFs establish communication with cancer cells through paracrine mechanisms or via direct cell adhesion as well as influence the cancer cell behaviour indirectly by remodelling the extracellular matrix. Although numerous studies have strongly suggested the tumor promoting role of CAFs, few recent reports have revealed the heterogeneity in CAFs. Here, we have summarized the recent findings on the mechanisms related to the heterogeneous behaviour of CAFs serving as positive or negative regulator of tumor progression. Further, reports related to the targeted therapy against CAF-mediated mechanisms are also summarized briefly. |
| first_indexed | 2024-12-12T20:54:23Z |
| format | Article |
| id | doaj.art-9198d354002a4c4b8fc5abcb62a9411c |
| institution | Directory Open Access Journal |
| issn | 2768-6701 |
| language | English |
| last_indexed | 2024-12-12T20:54:23Z |
| publishDate | 2020-03-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj.art-9198d354002a4c4b8fc5abcb62a9411c2022-12-22T00:12:20ZengIMR PressFrontiers in Bioscience-Landmark2768-67012020-03-0125596197810.2741/4843FBS-25-961Cancer associated fibroblasts: phenotypic and functional heterogeneityAnkit Kumar Patel0Sandeep Singh1National Institute of Biomedical Genomics, Kalyani, WB, IndiaNational Institute of Biomedical Genomics, Kalyani, WB, IndiaCancer associated fibroblasts (CAFs) are the most abundant stromal cell-type in solid tumor-microenvironment (TME) and have emerged as key player in tumor progression. CAFs establish communication with cancer cells through paracrine mechanisms or via direct cell adhesion as well as influence the cancer cell behaviour indirectly by remodelling the extracellular matrix. Although numerous studies have strongly suggested the tumor promoting role of CAFs, few recent reports have revealed the heterogeneity in CAFs. Here, we have summarized the recent findings on the mechanisms related to the heterogeneous behaviour of CAFs serving as positive or negative regulator of tumor progression. Further, reports related to the targeted therapy against CAF-mediated mechanisms are also summarized briefly.https://www.imrpress.com/journal/FBL/25/5/10.2741/4843cancer associated fibroblaststumor microenvironmentalpha-smooth muscle actincancer stem cellsheterogeneitymetastasisreview |
| spellingShingle | Ankit Kumar Patel Sandeep Singh Cancer associated fibroblasts: phenotypic and functional heterogeneity Frontiers in Bioscience-Landmark cancer associated fibroblasts tumor microenvironment alpha-smooth muscle actin cancer stem cells heterogeneity metastasis review |
| title | Cancer associated fibroblasts: phenotypic and functional heterogeneity |
| title_full | Cancer associated fibroblasts: phenotypic and functional heterogeneity |
| title_fullStr | Cancer associated fibroblasts: phenotypic and functional heterogeneity |
| title_full_unstemmed | Cancer associated fibroblasts: phenotypic and functional heterogeneity |
| title_short | Cancer associated fibroblasts: phenotypic and functional heterogeneity |
| title_sort | cancer associated fibroblasts phenotypic and functional heterogeneity |
| topic | cancer associated fibroblasts tumor microenvironment alpha-smooth muscle actin cancer stem cells heterogeneity metastasis review |
| url | https://www.imrpress.com/journal/FBL/25/5/10.2741/4843 |
| work_keys_str_mv | AT ankitkumarpatel cancerassociatedfibroblastsphenotypicandfunctionalheterogeneity AT sandeepsingh cancerassociatedfibroblastsphenotypicandfunctionalheterogeneity |