Intravenous route to choroidal neovascularization by macrophage-disguised nanocarriers for mTOR modulation

Intravenous route to choroidal neovascularization by macrophage-disguised nanocarriers for mTOR modulation

Retinal pigment epithelial (RPE) is primarily impaired in age-related macular degeneration (AMD), leading to progressive loss of photoreceptors and sometimes choroidal neovascularization (CNV). mTOR has been proposed as a promising therapeutic target, while the usage of its specific inhibitor, rapam...

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Bibliographic Details
Main Authors: Weiyi Xia, Chao Li, Qinjun Chen, Jiancheng Huang, Zhenhao Zhao, Peixin Liu, Kai Xu, Lei Li, Fangyuan Hu, Shujie Zhang, Tao Sun, Chen Jiang, Chen Zhao
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Choroidal neovascularization
Age-related macular degeneration
Biomimetic nanoparticles
Targeted drug delivery
mTOR signaling
Rapamycin
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521004251

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http://www.sciencedirect.com/science/article/pii/S2211383521004251

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