Topical Delivery of Tofacitinib in Dermatology: The Promise of a Novel Therapeutic Class Using Biodegradable Dendritic Polyglycerol Sulfates

Topical Delivery of Tofacitinib in Dermatology: The Promise of a Novel Therapeutic Class Using Biodegradable Dendritic Polyglycerol Sulfates

Inflammatory skin diseases, such as psoriasis, atopic dermatitis, and alopecia areata, occur when the regulatory tolerance of the innate immune system is disrupted, resulting in the activation of the Janus kinase-signal transducer and activator of transcription (JAK-STAT) inflammatory signaling path...

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Bibliographic Details
Main Authors: Fatemeh Zabihi, Mariam Cherri, Xiao Guo, Fiorenza Rancan, Fabian Schumacher, Ehsan Mohammadifar, Burkhard Kleuser, Wolfgang Bäumer, Michael Schirner, Annika Vogt, Rainer Haag
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Pharmaceuticals
Subjects:
inflammatory skin disease
JAK-STAT
tofacitinib
ex-vivo skin model
dPGS-PCL
interfollicular delivery
Online Access:https://www.mdpi.com/1424-8247/17/1/77

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https://www.mdpi.com/1424-8247/17/1/77

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