Shallow shotgun sequencing reduces technical variation in microbiome analysis

Abstract The microbiome is known to play a role in many human diseases, but identifying key microbes and their functions generally requires large studies due to the vast number of species and genes, and the high levels of intra-individual and inter-individual variation. 16S amplicon sequencing of th...

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Bibliographic Details
Main Authors: Alex J. La Reau, Noah B. Strom, Ellen Filvaroff, Konstantinos Mavrommatis, Tonya L. Ward, Dan Knights
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-33489-1