Deducing the stage of origin of Wilms' tumours from a developmental series of Wt1-mutant mice

Deducing the stage of origin of Wilms' tumours from a developmental series of Wt1-mutant mice

Wilms' tumours, paediatric kidney cancers, are the archetypal example of tumours caused through the disruption of normal development. The genetically best-defined subgroup of Wilms' tumours is the group caused by biallelic loss of the WT1 tumour suppressor gene. Here, we describe a develop...

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Bibliographic Details
Main Authors: Rachel L. Berry, Derya D. Ozdemir, Bruce Aronow, Nils O. Lindström, Tatiana Dudnakova, Anna Thornburn, Paul Perry, Richard Baldock, Chris Armit, Anagha Joshi, Cécile Jeanpierre, Jingdong Shan, Seppo Vainio, James Baily, David Brownstein, Jamie Davies, Nicholas D. Hastie, Peter Hohenstein
Format: Article
Language:English
Published: The Company of Biologists 2015-08-01
Series:Disease Models & Mechanisms
Subjects:
WT1
Wilms’ tumour
Kidney development
Mouse model
Online Access:http://dmm.biologists.org/content/8/8/903

Internet

http://dmm.biologists.org/content/8/8/903

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