Pathogen-specific structural features of Candida albicans Ras1 activation complex: uncovering new antifungal drug targets

Pathogen-specific structural features of Candida albicans Ras1 activation complex: uncovering new antifungal drug targets

ABSTRACT An important feature associated with Candida albicans pathogenicity is its ability to switch between yeast and hyphal forms, a process in which CaRas1 plays a key role. CaRas1 is activated by the guanine nucleotide exchange factor (GEF) CaCdc25, triggering hyphal growth-related signaling pa...

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Bibliographic Details
Main Authors: José A. Manso, Arturo Carabias, Zsuzsa Sárkány, José M. de Pereda, Pedro José Barbosa Pereira, Sandra Macedo-Ribeiro
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:mBio
Subjects:
Ras-like protein 1
cell division control protein 25
X-ray crystallography
small angle X-ray scattering
polyQ
Online Access:https://journals.asm.org/doi/10.1128/mbio.00638-23

Internet

https://journals.asm.org/doi/10.1128/mbio.00638-23

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