Ligand-based pharmacophore modelling in search of novel anaplastic lymphoma kinase inhibitors

Non-small-cell lung cancer (NSCLC) accounts for 85 % of lung cancer cases and is the leading cause of mortality globally. Anaplastic lymphoma kinase (ALK) has been identified as an NSCLC mutational cancer mediator. Many additional ALK inhibitors are currently undergoing clinical studies. Many ALK in...

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Bibliographic Details
Main Authors: V. Pratap Reddy Gajulapalli, Juyong Lee, Insuk Sohn
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Results in Chemistry
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715622004714