Overexpression of <i>Isl1</i> under the <i>Pax2</i> Promoter, Leads to Impaired Sound Processing and Increased Inhibition in the Inferior Colliculus

Overexpression of <i>Isl1</i> under the <i>Pax2</i> Promoter, Leads to Impaired Sound Processing and Increased Inhibition in the Inferior Colliculus

The LIM homeodomain transcription factor ISL1 is essential for the different aspects of neuronal development and maintenance. In order to study the role of ISL1 in the auditory system, we generated a transgenic mouse (<i>Tg</i>) expressing <i>Isl1</i> under the <i>Pax2&...

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Bibliographic Details
Main Authors: Tetyana Chumak, Diana Tothova, Iva Filova, Zbynek Bures, Jiri Popelar, Gabriela Pavlinkova, Josef Syka
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
transcription factor ISL1
auditory system
sound processing
inferior colliculus
inhibition
Online Access:https://www.mdpi.com/1422-0067/22/9/4507

Internet

https://www.mdpi.com/1422-0067/22/9/4507

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