Imatinib Mesylate Reduces Voiding Frequency in Female Mice With Acute Cyclophosphamide-Induced Cystitis

Imatinib Mesylate Reduces Voiding Frequency in Female Mice With Acute Cyclophosphamide-Induced Cystitis

Lamina propria interstitial cells that express the tyrosine kinase receptor, platelet-derived growth factor receptor alpha (PDGFRα) may play a role in urinary sensory signaling. Imatinib mesylate, also referred to as imatinib, is a tyrosine kinase inhibitor that can inhibit PDGFRα and has been widel...

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Bibliographic Details
Main Authors: Megan E. Perkins, Beatrice M. Girard, Susan E. Campbell, Margaret A. Vizzard
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Systems Neuroscience
Subjects:
interstitial cystitis
interstitial cells
platelet-derived growth factor receptor (PDGFR)
imatinib mesylate
conscious cystometry
somatic sensitivity
Online Access:https://www.frontiersin.org/articles/10.3389/fnsys.2022.867875/full

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https://www.frontiersin.org/articles/10.3389/fnsys.2022.867875/full

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