Pharmacokinetics, bioavailability, and plasma protein binding study of glytrexate, a novel multitarget antifolate

Pharmacokinetics, bioavailability, and plasma protein binding study of glytrexate, a novel multitarget antifolate

Glytrexate, developed by our team, as a novel multitarget folate antagonist, has inhibitory effects on a variety of cancer cell types, especially KB tumor cells (IC50 0.078 nM), and thus has antitumor drug development prospects. However, its pharmacokinetics and plasma protein binding properties rem...

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Bibliographic Details
Main Authors: Jiahong Xiang, Mengqi Wu, Jianchao Wang, Mengmeng Lin, Mengmeng Sun, Xin Li, Ruijuan Xing, Ran Guo, Jianmin Gu, Tao Lyu, Lei Wang, Xiaowei Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Pharmacology
Subjects:
pharmacokinetics
bioavailability
glytrexate
plasma protein binding
antifolate
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1001308/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.1001308/full

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