Nebulized fibrinolytic agents improve pulmonary fibrinolysis but not inflammation in rat models of direct and indirect acute lung injury.

Nebulized fibrinolytic agents improve pulmonary fibrinolysis but not inflammation in rat models of direct and indirect acute lung injury.

BACKGROUND: Critically ill patients frequently develop acute lung injury (ALI). Disturbed alveolar fibrin turnover, a characteristic feature of ALI, is the result of both activation of coagulation and inhibition of fibrinolysis. Nebulized fibrinolytic agents could exert lung-protective effects, via...

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Bibliographic Details
Main Authors: Jorrit J Hofstra, Alexander D Cornet, Paul J Declerck, Barry Dixon, Hamid Aslami, Alexander P J Vlaar, Joris J Roelofs, Tom van der Poll, Marcel Levi, Marcus J Schultz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3567078?pdf=render

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http://europepmc.org/articles/PMC3567078?pdf=render

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