Astrocytes Differentiated from LRRK2-I1371V Parkinson’s-Disease-Induced Pluripotent Stem Cells Exhibit Similar Yield but Cell-Intrinsic Dysfunction in Glutamate Uptake and Metabolism, ATP Generation, and Nrf2-Mediated Glutathione Machinery

Astrocytes Differentiated from LRRK2-I1371V Parkinson’s-Disease-Induced Pluripotent Stem Cells Exhibit Similar Yield but Cell-Intrinsic Dysfunction in Glutamate Uptake and Metabolism, ATP Generation, and Nrf2-Mediated Glutathione Machinery

Owing to the presence of multiple enzymatic domains, LRRK2 has been associated with a diverse set of cellular functions and signaling pathways. It also has several pathological mutant-variants, and their incidences show ethnicity biases and drug-response differences with expression in dopaminergic-n...

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Bibliographic Details
Main Authors: Roon Banerjee, Aishwarya Raj, Chandrakanta Potdar, Pramod Kumar Pal, Ravi Yadav, Nitish Kamble, Vikram Holla, Indrani Datta
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Cells
Subjects:
mutations in LRRK2 GTPase domain
glutamate uptake and metabolism
glutamate dehydrogenase
glutamate transporters
glutamate to glutamine
glutathione
Online Access:https://www.mdpi.com/2073-4409/12/12/1592

Internet

https://www.mdpi.com/2073-4409/12/12/1592

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