Polygenic risk score for hypercholesterolemia in a Brazilian familial hypercholesterolemia cohort

Polygenic risk score for hypercholesterolemia in a Brazilian familial hypercholesterolemia cohort

Background and aims: Familial hypercholesterolemia (FH) is a genetic disorder characterized by high levels of LDL-C leading to premature cardiovascular disease (CAD). Only about 40% of individuals with a clinical diagnosis of FH have a causative genetic variant identified, and a proportion of geneti...

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Bibliographic Details
Main Authors: Isabella Ramos Lima, Mauricio Teruo Tada, Theo G.M. Oliveira, Cinthia Elim Jannes, Isabela Bensenor, Paulo A. Lotufo, Raul D. Santos, Jose E. Krieger, Alexandre C. Pereira
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:Atherosclerosis Plus
Subjects:
Polygenic risk score
Familial hypercholesterolemia
Genetics
Lipid disorder
Atherosclerosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2667089522000190

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http://www.sciencedirect.com/science/article/pii/S2667089522000190

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