Combining rare and common genetic variants improves population risk stratification for breast cancer

Combining rare and common genetic variants improves population risk stratification for breast cancer

Purpose: This study aimed to evaluate the performance of different genetic screening approaches to identify women at high risk of breast cancer in the general population. Methods: We retrospectively studied 25,591 women with available electronic health records and genetic data, participants in the H...

Full description

Bibliographic Details
Main Authors: Alexandre Bolze, Daniel Kiser, Kelly M. Schiabor Barrett, Gai Elhanan, Jamie M. Schnell Blitstein, Iva Neveux, Shaun Dabe, Harry Reed, Alexa Anderson, William J. Metcalf, Ekaterina Orlova, Ildiko Thibodeau, Natalie Telis, Ruomu Jiang, Nicole L. Washington, Matthew J. Ferber, Catherine Hajek, Elizabeth T. Cirulli, Joseph J. Grzymski
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Genetics in Medicine Open
Subjects:
ATM and CHEK2
Breast cancer
Family history
Polygenic risk score
Population screening
Online Access:http://www.sciencedirect.com/science/article/pii/S2949774424009725

Internet

http://www.sciencedirect.com/science/article/pii/S2949774424009725

Similar Items