Targeted Nano-Drug Delivery of Colchicine against Colon Cancer Cells by Means of Mesoporous Silica Nanoparticles

Targeted Nano-Drug Delivery of Colchicine against Colon Cancer Cells by Means of Mesoporous Silica Nanoparticles

Antimitotics are important anticancer agents and include the natural alkaloid prodrug colchicine (COL). However, a major challenge of using COL as an anticancer drug is its cytotoxicity. We developed a novel drug delivery system (DDS) for COL using mesoporous silica nanoparticles (MSNs). The MSNs we...

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Bibliographic Details
Main Authors: Khaled AbouAitah, Heba A. Hassan, Anna Swiderska-Sroda, Lamiaa Gohar, Olfat G. Shaker, Jacek Wojnarowicz, Agnieszka Opalinska, Julita Smalc-Koziorowska, Stanislaw Gierlotka, Witold Lojkowski
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cancers
Subjects:
colchicine alkaloid
colon cancer cells
mesoporous silica nanoparticles
targeted delivery system
apoptosis
pd-1 immune checkpoint inhibitor and cancer immunotherapy
Online Access:https://www.mdpi.com/2072-6694/12/1/144

Internet

https://www.mdpi.com/2072-6694/12/1/144

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