The deubiquitinase EIF3H promotes hepatocellular carcinoma progression by stabilizing OGT and inhibiting ferroptosis

The deubiquitinase EIF3H promotes hepatocellular carcinoma progression by stabilizing OGT and inhibiting ferroptosis

Abstract Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal human malignancies, and with quite limited treatment alternatives. The proteasome is responsible for most of the protein degradation in eukaryotic cells and required for the maintenance of intracellular homeostasis. Howe...

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Bibliographic Details
Main Authors: Jianing Tang, Guo Long, Xuanxuan Li, Ledu Zhou, Yangying Zhou, Zheyu Wu
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Cell Communication and Signaling
Subjects:
Hepatocellular carcinoma
EIF3H
OGT
Ferroptosis
Deubiquitination
Online Access:https://doi.org/10.1186/s12964-023-01220-2

Internet

https://doi.org/10.1186/s12964-023-01220-2

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