HLA-B*57:01 allele prevalence in HIV-infected North American subjects and the impact of allele testing on the incidence of abacavir-associated hypersensitivity reaction in HLA-B*57:01-negative subjects

HLA-B*57:01 allele prevalence in HIV-infected North American subjects and the impact of allele testing on the incidence of abacavir-associated hypersensitivity reaction in HLA-B*57:01-negative subjects

Abstract Background The presence of the HLA-B*57:01 allele in HIV-infected subjects is associated with a higher risk of abacavir-associated hypersensitivity reaction (ABC HSR). HLA-B*57:01 allele prevalence varies in different populations, but HLA-B*57:01 testing with immunological confirmation has...

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Bibliographic Details
Main Authors: Catherine Butkus Small, David A. Margolis, Mark S. Shaefer, Lisa L. Ross
Format: Article
Language:English
Published: BMC 2017-04-01
Series:BMC Infectious Diseases
Subjects:
Abacavir
Lamivudine
Hypersensitivity
HLA-B*57:01
HIV infection
Online Access:http://link.springer.com/article/10.1186/s12879-017-2331-y

Internet

http://link.springer.com/article/10.1186/s12879-017-2331-y

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