HLA-B*57:01 allele prevalence in HIV-infected North American subjects and the impact of allele testing on the incidence of abacavir-associated hypersensitivity reaction in HLA-B*57:01-negative subjects

HLA-B*57:01 allele prevalence in HIV-infected North American subjects and the impact of allele testing on the incidence of abacavir-associated hypersensitivity reaction in HLA-B*57:01-negative subjects

Abstract Background The presence of the HLA-B*57:01 allele in HIV-infected subjects is associated with a higher risk of abacavir-associated hypersensitivity reaction (ABC HSR). HLA-B*57:01 allele prevalence varies in different populations, but HLA-B*57:01 testing with immunological confirmation has...

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Bibliografiset tiedot
Päätekijät: Catherine Butkus Small, David A. Margolis, Mark S. Shaefer, Lisa L. Ross
Aineistotyyppi: Artikkeli
Kieli:English
Julkaistu: BMC 2017-04-01
Sarja:BMC Infectious Diseases
Aiheet:
Abacavir
Lamivudine
Hypersensitivity
HLA-B*57:01
HIV infection
Linkit:http://link.springer.com/article/10.1186/s12879-017-2331-y

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