Neuron–Microglia Contacts Govern the PGE<sub>2</sub> Tolerance through TLR4-Mediated de Novo Protein Synthesis

Neuron–Microglia Contacts Govern the PGE<sub>2</sub> Tolerance through TLR4-Mediated de Novo Protein Synthesis

Cellular and molecular mechanisms of the peripheral immune system (e.g., macrophage and monocyte) in programming endotoxin tolerance (ET) have been well studied. However, regulatory mechanism in development of brain immune tolerance remains unclear. The inducible COX-2/PGE<sub>2</sub> ax...

Full description

Bibliographic Details
Main Authors: Hsing-Chun Kuo, Kam-Fai Lee, Shiou-Lan Chen, Shu-Chen Chiu, Li-Ya Lee, Wan-Ping Chen, Chin-Chu Chen, Chun-Hsien Chu
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Biomedicines
Subjects:
PGE<sub>2</sub>
COX-2
microglia
endotoxin tolerance
cell–cell contacts
TLR4
Online Access:https://www.mdpi.com/2227-9059/10/2/419

Internet

https://www.mdpi.com/2227-9059/10/2/419

Similar Items