Dimethyl itaconate ameliorates cognitive impairment induced by a high-fat diet via the gut-brain axis in mice

Dimethyl itaconate ameliorates cognitive impairment induced by a high-fat diet via the gut-brain axis in mice

Abstract Background Gut homeostasis, including intestinal immunity and microbiome, is essential for cognitive function via the gut-brain axis. This axis is altered in high-fat diet (HFD)-induced cognitive impairment and is closely associated with neurodegenerative diseases. Dimethyl itaconate (DI) i...

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Bibliographic Details
Main Authors: Wei Pan, Jinxiu Zhao, Jiacheng Wu, Daxiang Xu, Xianran Meng, Pengfei Jiang, Hongli Shi, Xing Ge, Xiaoying Yang, Minmin Hu, Peng Zhang, Renxian Tang, Nathan Nagaratnam, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Microbiome
Subjects:
Itaconate
Cognition
Obesity
Gut microbiome
Microglia
Gut-brain axis
Online Access:https://doi.org/10.1186/s40168-023-01471-8

Internet

https://doi.org/10.1186/s40168-023-01471-8

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