Proteomic and histopathological characterisation of sicca subjects and primary Sjögren’s syndrome patients reveals promising tear, saliva and extracellular vesicle disease biomarkers

Proteomic and histopathological characterisation of sicca subjects and primary Sjögren’s syndrome patients reveals promising tear, saliva and extracellular vesicle disease biomarkers

Abstract Background Mononuclear cell infiltration of exocrine glands, production of Ro/SSA and La/SSB autoantibodies, along with oral and ocular dryness, are characteristic features of primary Sjögren’s syndrome (pSS). Non-SS sicca subjects, an underexplored group in relation to pSS, display similar...

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Bibliographic Details
Main Authors: Lara A. Aqrawi, Hilde Kanli Galtung, Eduarda M. Guerreiro, Reidun Øvstebø, Bernd Thiede, Tor Paaske Utheim, Xiangjun Chen, Øygunn Aass Utheim, Øyvind Palm, Kathrine Skarstein, Janicke Liaaen Jensen
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Arthritis Research & Therapy
Subjects:
Sjögren’s syndrome
Autoimmunity
Sicca subjects
Proteomics
Biomarkers
Innate immunity
Online Access:http://link.springer.com/article/10.1186/s13075-019-1961-4

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http://link.springer.com/article/10.1186/s13075-019-1961-4

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