Chemoselective Synthesis of Mannich Adducts from 1,4-Naphthoquinones and Profile as Autophagic Inducers in Oral Squamous Cell Carcinoma

Chemoselective Synthesis of Mannich Adducts from 1,4-Naphthoquinones and Profile as Autophagic Inducers in Oral Squamous Cell Carcinoma

Oral squamous cell carcinoma (OSCC) is a worldwide public health problem, accounting for approximately 90% of all oral cancers, and is the eighth most common cancer in men. Cisplatin and carboplatin are the main chemotherapy drugs used in the clinic. However, in addition to their serious side effect...

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Bibliographic Details
Main Authors: Amanda A. Borges, Michele P. de Souza, Anna Carolina C. da Fonseca, Guilherme F. Wermelinger, Ruan C. B. Ribeiro, Adriane A. P. Amaral, Cláudio José C. de Carvalho, Lucas S. Abreu, Lucas Nicolau de Queiroz, Elan C. P. de Almeida, Vitor W. Rabelo, Paula A. Abreu, Bruno Pontes, Vitor F. Ferreira, Fernando de C. da Silva, Luana da S. M. Forezi, Bruno K. Robbs
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
oral squamous cell carcinoma
lawsone
lapachol
Mannich adducts
pyruvate kinase M2
autophagy
Online Access:https://www.mdpi.com/1420-3049/28/1/309

Internet

https://www.mdpi.com/1420-3049/28/1/309

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