Arteriovenous malformation Map2k1 mutation affects vasculogenesis

Arteriovenous malformation Map2k1 mutation affects vasculogenesis

Abstract Somatic activating MAP2K1 mutations in endothelial cells (ECs) cause extracranial arteriovenous malformation (AVM). We previously reported the generation of a mouse line allowing inducible expression of constitutively active MAP2K1 (p.K57N) from the Rosa locus (R26 GT-Map2k1-GFP/+) and show...

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Bibliographic Details
Main Authors: Christopher L. Sudduth, Patrick J. Smits, Matthew P. Vivero, Yu Sheng Cheng, Michal Ad, Dennis J. Konczyk, Joyce Bischoff, Matthew L. Warman, Arin K. Greene
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-35301-6

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https://doi.org/10.1038/s41598-023-35301-6

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