GluA3 subunits are required for appropriate assembly of AMPAR GluA2 and GluA4 subunits on cochlear afferent synapses and for presynaptic ribbon modiolar–pillar morphology

GluA3 subunits are required for appropriate assembly of AMPAR GluA2 and GluA4 subunits on cochlear afferent synapses and for presynaptic ribbon modiolar–pillar morphology

Cochlear sound encoding depends on α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs), but reliance on specific pore-forming subunits is unknown. With 5-week-old male C57BL/6J Gria3-knockout mice (i.e., subunit GluA3KO) we determined cochlear function, synapse ultrastructure, a...

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Bibliographic Details
Main Authors: Mark A Rutherford, Atri Bhattacharyya, Maolei Xiao, Hou-Ming Cai, Indra Pal, Maria Eulalia Rubio
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-01-01
Series:eLife
Subjects:
glutamate receptors
inner hair cells
confocal imaging
3D reconstructions
qRT-PCR
immunolabeling
Online Access:https://elifesciences.org/articles/80950

Internet

https://elifesciences.org/articles/80950

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