Ythdf2 promotes pulmonary hypertension by suppressing Hmox1-dependent anti-inflammatory and antioxidant function in alveolar macrophages

Ythdf2 promotes pulmonary hypertension by suppressing Hmox1-dependent anti-inflammatory and antioxidant function in alveolar macrophages

Pulmonary hypertension (PH) is a devastating disease characterized by irreversible pulmonary vascular remodeling (PVR) that causes right ventricular failure and death. The early alternative activation of macrophages is a critical event in the development of PVR and PH, but the underlying mechanisms...

Full description

Bibliographic Details
Main Authors: Li Hu, Yanfang Yu, Yueyao Shen, Huijie Huang, Donghai Lin, Kang Wang, Youjia Yu, Kai Li, Yue Cao, Qiang Wang, Xiaoxuan Sun, Zhibing Qiu, Dong Wei, Bin Shen, Jingyu Chen, David Fulton, Yong Ji, Jie Wang, Feng Chen
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Redox Biology
Subjects:
Alveolar macrophages
Oxidant stress
Inflammation
Ythdf2
Heme oxygenase 1
Pulmonary hypertension
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723000393

Internet

http://www.sciencedirect.com/science/article/pii/S2213231723000393

Similar Items