Roux-en-Y Gastric Bypass and Caloric Restriction but Not Gut Hormone-Based Treatments Profoundly Impact the Hypothalamic Transcriptome in Obese Rats

Roux-en-Y Gastric Bypass and Caloric Restriction but Not Gut Hormone-Based Treatments Profoundly Impact the Hypothalamic Transcriptome in Obese Rats

Background: The hypothalamus is an important brain region for the regulation of energy balance. Roux-en-Y gastric bypass (RYGB) surgery and gut hormone-based treatments are known to reduce body weight, but their effects on hypothalamic gene expression and signaling pathways are poorly studied. Metho...

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Bibliographic Details
Main Authors: Ulrich Dischinger, Tobias Heckel, Thorsten Bischler, Julia Hasinger, Malina Königsrainer, Angelika Schmitt-Böhrer, Christoph Otto, Martin Fassnacht, Florian Seyfried, Mohammed Khair Hankir
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Nutrients
Subjects:
obesity
Roux-en-Y gastric bypass surgery
liraglutide
PYY3-36
hypothalamic gene expression
Online Access:https://www.mdpi.com/2072-6643/14/1/116

Internet

https://www.mdpi.com/2072-6643/14/1/116

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