Abnormal molecular signatures of inflammation, energy metabolism, and vesicle biology in human Huntington disease peripheral tissues

Abnormal molecular signatures of inflammation, energy metabolism, and vesicle biology in human Huntington disease peripheral tissues

Abstract Background A major challenge in neurodegenerative diseases concerns identifying biological disease signatures that track with disease progression or respond to an intervention. Several clinical trials in Huntington disease (HD), an inherited, progressive neurodegenerative disease, are curre...

Full description

Bibliographic Details
Main Authors: Andreas Neueder, Kerstin Kojer, Tanja Hering, Daniel J. Lavery, Jian Chen, Nathalie Birth, Jaqueline Hallitsch, Sonja Trautmann, Jennifer Parker, Michael Flower, Huma Sethi, Salman Haider, Jong-Min Lee, Sarah J. Tabrizi, Michael Orth
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Genome Biology
Subjects:
Neurodegeneration
Transcriptomics
Proteomics
SNP sequencing
Skeletal muscle
Adipose tissue
Online Access:https://doi.org/10.1186/s13059-022-02752-5

Internet

https://doi.org/10.1186/s13059-022-02752-5

Similar Items