How Do Molecular Dynamics Data Complement Static Structural Data of GPCRs

How Do Molecular Dynamics Data Complement Static Structural Data of GPCRs

G protein-coupled receptors (GPCRs) are implicated in nearly every physiological process in the human body and therefore represent an important drug targeting class. Advances in X-ray crystallography and cryo-electron microscopy (cryo-EM) have provided multiple static structures of GPCRs in complex...

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Bibliographic Details
Main Authors: Mariona Torrens-Fontanals, Tomasz Maciej Stepniewski, David Aranda-García, Adrián Morales-Pastor, Brian Medel-Lacruz, Jana Selent
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
GPCRs
molecular dynamics
ligand binding
receptor (in)activation
receptor signaling
drug discovery
Online Access:https://www.mdpi.com/1422-0067/21/16/5933

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https://www.mdpi.com/1422-0067/21/16/5933

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