Constructing “smart” chelators by using an activatable prochelator strategy for the treatment of Wilson's disease

Constructing “smart” chelators by using an activatable prochelator strategy for the treatment of Wilson's disease

Wilson's disease (WD) is a genetic disorder that primarily leads to the pathological accumulation of copper (Cu) in the liver, causing an abnormal increase in reactive oxygen species (ROS). The prevailing clinical therapy for WD involves lifelong use of Cu chelation drugs to facilitate Cu excre...

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Bibliographic Details
Main Authors: Chengcheng Wang, Roumin Wang, Lingzhou Zhao, Shasha Wang, Yan Liu, Jinhua Zhao, Yi Dong, Lingyan Liu, Peng Wei, Zhi-Ying Wu, Tao Yi
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Redox Biology
Subjects:
Wilson's disease
Reactive oxygen species
Copper
Prochelator
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724000521

Internet

http://www.sciencedirect.com/science/article/pii/S2213231724000521

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