CRISPR/Cas9 Genome Editing Reveals That the Intron Is Not Essential for <italic toggle="yes">var2csa</italic> Gene Activation or Silencing in <italic toggle="yes">Plasmodium falciparum</italic>

CRISPR/Cas9 Genome Editing Reveals That the Intron Is Not Essential for <italic toggle="yes">var2csa</italic> Gene Activation or Silencing in <italic toggle="yes">Plasmodium falciparum</italic>

ABSTRACT Plasmodium falciparum relies on monoallelic expression of 1 of 60 var virulence genes for antigenic variation and host immune evasion. Each var gene contains a conserved intron which has been implicated in previous studies in both activation and repression of transcription via several epige...

Full description

Bibliographic Details
Main Authors: Jessica M. Bryant, Clément Regnault, Christine Scheidig-Benatar, Sebastian Baumgarten, Julien Guizetti, Artur Scherf
Format: Article
Language:English
Published: American Society for Microbiology 2017-09-01
Series:mBio
Subjects:
CRISPR/Cas9
Plasmodium falciparum
antigenic variation
transcriptional regulation
var genes
Online Access:https://journals.asm.org/doi/10.1128/mBio.00729-17

Internet

https://journals.asm.org/doi/10.1128/mBio.00729-17

Similar Items