Design, synthesis and biological evaluation of novel podophyllotoxin derivatives as tubulin-targeting anticancer agents

Design, synthesis and biological evaluation of novel podophyllotoxin derivatives as tubulin-targeting anticancer agents

AbstractContext Podophyllotoxin (PPT) derivatives, used in cancer therapy, require development toward enhanced efficacy and reduced toxicity.Objective This study synthesizes PPT derivatives to assess their anticancer activities.Materials and methods Compounds E1-E16 antiproliferative activity was te...

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Bibliographic Details
Main Authors: Yujin Guo, Beibei Chen, Jinxiu Guo, Pei Jiang, Jianhua Wang, Wenxue Sun
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Pharmaceutical Biology
Subjects:
Tubulin
apoptosis
lung adenocarcinoma epithelial
PI3K/akt signalling pathway
compound synthesis
Online Access:https://www.tandfonline.com/doi/10.1080/13880209.2024.2318350

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https://www.tandfonline.com/doi/10.1080/13880209.2024.2318350

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