TopBP1 utilises a bipartite GINS binding mode to support genome replication

TopBP1 utilises a bipartite GINS binding mode to support genome replication

Abstract Activation of the replicative Mcm2-7 helicase by loading GINS and Cdc45 is crucial for replication origin firing, and as such for faithful genetic inheritance. Our biochemical and structural studies demonstrate that the helicase activator GINS interacts with TopBP1 through two separate bind...

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Bibliographic Details
Main Authors: Matthew Day, Bilal Tetik, Milena Parlak, Yasser Almeida-Hernández, Markus Räschle, Farnusch Kaschani, Heike Siegert, Anika Marko, Elsa Sanchez-Garcia, Markus Kaiser, Isabel A. Barker, Laurence H. Pearl, Antony W. Oliver, Dominik Boos
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45946-0

Internet

https://doi.org/10.1038/s41467-024-45946-0

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