Reduced intrinsic DNA curvature leads to increased mutation rate

Reduced intrinsic DNA curvature leads to increased mutation rate

Abstract Background Mutation rates vary across the genome. Many trans factors that influence mutation rates have been identified, as have specific sequence motifs at the 1–7-bp scale, but cis elements remain poorly characterized. The lack of understanding regarding why different sequences have diffe...

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Bibliographic Details
Main Authors: Chaorui Duan, Qing Huan, Xiaoshu Chen, Shaohuan Wu, Lucas B. Carey, Xionglei He, Wenfeng Qian
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Genome Biology
Subjects:
DNA shape
Intrinsic DNA curvature
Mutation rate
Mutational landscape
Mutagen sensitivity
Online Access:http://link.springer.com/article/10.1186/s13059-018-1525-y

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http://link.springer.com/article/10.1186/s13059-018-1525-y

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