AQP9 transports lactate in tumor-associated macrophages to stimulate an M2-like polarization that promotes colon cancer progression

AQP9 transports lactate in tumor-associated macrophages to stimulate an M2-like polarization that promotes colon cancer progression

Macrophages play a major role in the immune defense against pathogenic factors; however, they can lead to tumor exacerbation and metastasis, as the tumor microenvironment (TME) polarizes tumor-associated macrophages (TAMs) into the M2 subtype. Lactate, a metabolite produced by carcinoma cells at hig...

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Bibliographic Details
Main Authors: Yundi Shi, Masato Yasui, Mariko Hara-Chikuma
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Biochemistry and Biophysics Reports
Subjects:
AQP9
Tumor-associated macrophages
Lactate
Tumor microenvironment
Colon cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580822001170

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http://www.sciencedirect.com/science/article/pii/S2405580822001170

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